Southwest Airlines is proud to serve John Wayne Airport Orange County.
If you are looking to trek north up the California coast or slip the state line and head east, you’ll find convenient flights from Southwest out of Orange County/Santa Ana that get you where you need to go. Likewise, you’ll find a conveniently located launchpad from which to start your next adventure in John Wayne Airport Orange County.
Peruse all of the locations that Southwest Airlines flies from Orange County/Santa Ana to discover destinations for your next trip out of SoCal. Whether you’ve got your sights set on snowcapped mountains or the busy streets of a city away from home, you’ll find a number of options with Southwest.
Southwest makes it simple to trade the same old same old for something new. Plan your next voyage with the help of the list of destinations below. And once you’ve chosen where to travel, you can find add-ons like tours, travel bundles, and exciting activities to enjoy after you’ve arrived. Book your next trip, earn Rapid Rewards® points, and enjoy a straightforward process all the way from booking to boarding. See what else goes into making your trip a memorable one and learn more about the complete Southwest® Experience today.
Wade into the adventure that awaits you in Golden Gate City. Enjoy West Coast vibes—book your flight to San Francisco today and get ready to be wowed by the City by the Bay.
*Fares are updated hourly. Fares displayed on external channels may no longer be available at time of booking. To find the most updated fare, please visit Southwest.com. Restrictions and exclusions apply. Seats and dates are limited. Fares may vary by destination, flight, and day of week and won't be available on some flights that operate during very busy travel times and holiday periods.
Got flexible travel plans?
Use our Low Fare Calendar to find the lowest fares on flights from Orange County/Santa Ana available inside your travel window.
Cities with daily nonstop flights Monday through Friday from SNA
10‡
Cities with daily nonstop flights Saturday through Sunday from SNA
9§
*Fares are updated hourly. Fares displayed on external channels may no longer be available at time of booking. To find the most updated fare, please visit Southwest.com. Restrictions and exclusions apply. Seats and dates are limited. Fares may vary by destination, flight, and day of week and won't be available on some flights that operate during very busy travel times and holiday periods.
†Weekly flights based on DOT published scheduled average flights Monday through Sunday between 5/1/2025 and 5/31/2025. Note: route may not operate every day of the week.
‡Nonstop flights based on DOT published scheduled average flights Monday through Friday between 5/1/2025 and 5/31/2025.
§Nonstop flights based on DOT published scheduled average flights Saturday through Sunday between 5/1/2025 and 5/31/2025.
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Your points don’t expire.
You can earn points on flights and on everyday purchases with our partners, which makes getting to your destination easy. No matter when, or where, you earn them, your points won’t expire.
